YILIMART - Anti-CX3CR1 MicroBead Kit, human

Anti-CX3CR1 MicroBead Kit, human

For research use only

货号：: 130-099-032
描述：: Anti-CX3CR1 MicroBead Kit, human
包装：: for up to 1×10⁹ total cells

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The Anti-CX3CR1 MicroBead Kit, human has been designed for the isolation of CX3CR1

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cells from peripheral blood mononuclear cells.

Background information

CX3CR1 is a transmembrane chemokine receptor with a molecular mass of 40 kDa. It binds the chemokine CX3CL1, also known as fractalkine or neurotactin. Binding of CX3CR1 to the membrane-bound form of fractalkine promotes cell-cell adhesion, whereas the soluble form induces cell migration of CX3CR1-expressing cells such as monocytes, NK cells, T cells, dendritic cells (DCs), and macrophages including microglia. CX3CR1 also plays an important role in the formation of transepithelial dendrites by intestinal DCs. Failure in the fractalkine/CX3CR1 interaction may contribute to the development of several inflammatory diseases including atherosclerosis, psoriasis, rheumatoid arthritis, and experimental autoimmune myositis.

Applications

Positive selection of CX3CR1-positive cells, e.g., after depleting cells of undesired lineage.

Columns

MS, LS, or autoMACS

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Columns.

Figure 1

Positive selection of CX3CR1

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cells from PBMCs using the Anti-CX3CR1 MicroBead Kit, an LS Column and a MidiMACS™ Separator. Cells were fluorescently stained with Anti-CX3CR1-PE and analyzed by flow cytometry using the MASCQuant

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Analyzer. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

PBMCs before separation	Enriched CX3CR1 ⁺ cells

PBMCs depleted of CX3CR1 ⁺ cells

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