Clone REAL328 is an antibody fragment derived from the full CD61 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.

Clone REAL328 recognizes the human CD61 antigen, a cell surface protein belonging to the integrin family. CD61 is also known as the integrin β3-subunit. It associates with CD41 to form the heterodimeric gpIIb/gpIIIa complex that is present on human megakaryocytes and platelets and mediates cell adhesion processes. Together with CD51, CD61 forms the vitronectin receptor, which is present on platelets as well as on a variety of other cell types such as osteoclasts and endothelial vessel cells. Clone REAL328 specifically recognizes the integrin β3-chain of both heterodimeric complexes.

The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.