YILIMART - Anti-TCR g/d-Biotin, mouse 200 tests

Clone REA633 recognizes the mouse TCRγ/δ antigen. The T cell receptor (TCR) is a heterodimeric glycoprotein associated with the CD3 antigen. It consists of an α and a β chain (TCRα/β) or a γ and a δ chain (TCRγ/δ). The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. The γ chain forms either disulfide-linked or non-disulfide-linked heterodimers with the δ-subunit. The γ/δ T cell receptor is present on a subset of T lymphocytes in peripheral blood. TCRγ/δ is involved in the antigen recognition of tumor-associated antigens or bacterial antigens presented by MHC class I molecules.

Additional information: Clone REA633 displays negligible binding to Fc receptors.

Alternative names

TCRgd

Technical specifications

Antigen: TCRγ/δ
Clone: REA633
Isotype: recombinant human IgG1
Isotype control: REA Control antibodies
Alternative names of antigen: TCRgd
Entrez Gene ID: 110066, 110067
Distribution of antigen: T cells
Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
Storage: Store protected from light at 2–8 °C. Do not freeze.
Available conjugates: FITC, APC, VioBlue, APC-Vio770, Biotin

Figure 1

Splenocytes from C57BL/6 mice were stained with Anti-TCRγ/δ antibodies or with the corresponding REA Control antibodies (left images) as well as with CD3ε antibodies. Flow cytometry was performed using the MACSQuant

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Analyzer. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence.

Selected references
1. Bonneville, M. et al. (2010) Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat. Rev. Immunol. 10(7): 467-478
2. Schmolka, N. et al. (2013) Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat. Immunol. 14(10): 1093-1100
3. Wiest, D. L. (2016) Development of γδ T cells, the special-force soldiers of the immune system. Methods Mol. Biol. 1323: 23-32

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Anti-TCR g/d-Biotin, mouse 200 tests

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Alternative names

Technical specifications

Figure 1

Selected references

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