Alternative names

Technical specifications

• Antigen: CD41/CD61
• Clone: REA607
• Isotype: recombinant human IgG1
• Isotype control: REA Control (S) antibodies
• Alternative names of antigen: gpIIb/IIIa complex, integrin αIIbβ3
• Entrez Gene ID: 3674, 3690
• Distribution of antigen: megakaryocytes, platelets
• Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
• Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
• Storage: Store protected from light at 2–8 °C. Do not freeze.
• Available conjugates: FITC, VioGreen, PE-Vio770, Biotin

• Figure 1

  Human platelets were stained with CD41/CD61 antibodies or with the corresponding REA Control (S) antibodies (left images) as well as with CD42a antibodies. Flow cytometry was performed using the MACSQuant ® Analyzer. The Tandem Signal Enhancer has been used to increase binding specificity of tandem-dye–conjugated antibodies. Cell debris and dead cells were excluded from the analysis based on scatter signals and propidium iodide fluorescence or 4',6-diamidino-2-phenylindole (DAPI) fluorescence, as in the case of tandem conjugates.

• Selected references

  1. Naik, U. P. et al. (1997) Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain. J. Biol. Chem. 272(8): 4651-4654
  2. Corbel, C. et al. (2005) (alpha)IIb integrin, a novel marker for hemopoietic progenitor cells. Int. J. Dev. Biol. 49(2-3): 279-284
  3. Podolnikova, N. P. et al. (2014) The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain. J. Biol. Chem. 289(4): 2371-2383