ExiTron nano 12000 is an alkaline earth metal-based nanoparticulate contrast agent specifically formulated for preclinical computed tomography (CT).
It shows strong X-ray absorption due to the high metal load of the particles.
Upon intravenous injection, ExiTron nano 12000 circulates in the blood stream for a prolonged time. It accumulates in the liver and spleen due to uptake by Kupffer cells (macrophages of the liver).
Applications
ExiTron nano 12000 is indicated for use in CT of small animals, for example mice, to facilitate the visualization of the vasculature.
Schematic diagram of an ExiTron nano 12000 nanoparticle.
Schematic diagram of an ExiTron nano 12000 nanoparticle.
Selected references
Boll, H. et al. (2010) High-speed single-breath-hold micro-computed tomography of thoracic and abdominal structures in mice using a simplified method for intubation. J. Comput. Assist. Tomogr. 34: 783-790
Boll, H. et al. (2011) Micro-CT based experimental liver imaging using a nanoparticulate contrast agent: a longitudinal study in mice. PLoS One 6: e25692
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