GadoSpin D is a dendritic gadolinium-based contrast agent of intermediate molecular weight specifically formulated for preclinical magnetic resonance imaging (MRI).
It is a contrast agent of high relaxivity increasing the signal intensity in T1-weighted MRI due to a shortening of the spin-lattice relaxation time (T1).
Upon intravenous injection, GadoSpin D remains within the vascular system. Significant extravasation can be observed in fenestrated blood vessels of inflamed tissue or tumors.
GadoSpin D is mainly excreted via glomerular filtration (kidneys).
Applications
GadoSpin D is indicated for use in MRI of small animals, for example, mice, to facilitate the visualization of the vasculature.
Examples include dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), tumor characterization and therapy monitoring.
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Fink, C. et al. (2003) High-resolution three-dimensional MR angiography of rodent tumors: morphologic characterization of intratumoral vasculature. J. Magn. Reson. Imaging 18: 59-65
Hamzah, J. et al. (2008) Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 453: 410-414
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