GadoSpin M is a gadolinium-based contrast agent of low molecular weight specifically formulated for pre-clinical magnetic resonance imaging (MRI).
GadoSpin M increases the signal intensity in T1-weighted MRI due to a shortening of the spin-lattice relaxation time (T1).
Upon intravenous injection, GadoSpin M is rapidly distributed in the extracellular space. No significant plasma protein–binding can be observed and the stable complex is excreted unchanged via glomerular filtration (kidneys) within hours.
Gd-DTPA does not penetrate the intact blood brain barrier and is, in fact, used in clinical practice for imaging of brain tumors.
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Bjornaes, I. et al. (2000) Measurement of the extracellular volume of human melanoma xenografts by contrast enhanced magnetic resonance imaging. Magn. Reson. Imaging 18: 41-48
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