NiraWave M is a micellar near-infrared (NIR) fluorescence contrast agent exhibiting a prolonged blood circulation and high quantum yield specifically formulated for pre-clinical optical imaging.
NiraWave M shows absorption and emission (fluorescence) in the NIR spectral range allowing an increased tissue penetration.
Due to the micellar formulation of indocyanine green, NiraWave M exhibits a stronger fluorescence, higher aqueous stability and prolonged blood circulation.
NiraWave M is excreted by the liver within hours.
Applications
NiraWave M is indicated for use in optical imaging of small animals, for example mice, to facilitate the visualization of the vasculature. Examples include fluorescence angiography and fenestration of blood vessels in inflamed tissue or tumors.
Normalized absorption and emission spectra of NiraWave™ M in plasma.
Normalized absorption and emission spectra of NiraWave™ M in plasma.
Selected references
Kirchherr, A. K. et al. (2009) Stabilization of indocyanine green by encapsulation within micellar systems. Mol. Pharm. 6: 480-491
Kirchherr, A.K. (2010) Herstellung und Charakterisierung kolloidaler Formulierungen für Indocyaningrün als Kontrastmittel für die optische Bildgebung. : Doctoral thesis
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