YILIMART - NiraWave C Optical Contrast Agent, 5×5

NiraWave C is a near-infrared (NIR) fluorescence contrast agent with high protein binding affinity specifically formulated for preclinical optical imaging.

It shows absorption and emission (fluorescence) in the NIR spectral range allowing an increased tissue penetration.

Upon intravenous injection, NiraWave C rapidly binds to plasma proteins and is excreted unchanged by the liver. The plasma clearance is biphasic with an initial half-life of 3–4 minutes and a secondary half-life of more than 1 hour.

Applications

NiraWave C is indicated for use in optical imaging of small animals, for example mice, to facilitate the visualization of the vasculature.

Examples include fluorescence angiography.

Figure 1
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Figure 1

Structural formula of indocyanine green.

Structural formula of indocyanine green.
Figure 2
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Figure 2

Normalized absorption and emission spectra of NiraWave C in plasma.

Normalized absorption and emission spectra of NiraWave C in plasma.

Selected references
1. Reynolds, J. S. et al. (1999) Imaging of spontaneous canine mammary tumors using fluorescent contrast agents. Photochem. Photobiol. 70: 87-94
2. Li et al. (1995) Proc. SPIE 2389: 789-797
3. Bäumler, W. et al. (1999) Photo-oxidative killing of human colonic cancer cells using indocyanine green and infrared light. Br. J. Cancer 80: 360-363

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NiraWave C Optical Contrast Agent, 5×5

For research use only

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Applications

Figure 1

Figure 1

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Figure 2

Selected references

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