Fibronectin (Fragment) is a recombinant protein optimized for use in cell culture as attachment matrix.
Applications
Human Fibronectin (Fragment) may be used for a variety of applications, including:
Culture of cardiomyocytes derived from pluripotent stem cells
Culture of mesenchymal stem cells (MSC)
Culture of isolated cardiomyocytes
Background information
Fibronectin is a high-molecular weight glycoprotein of the extracellular matrix. It is of major importance for cell adhesion, growth, migration, and differentiation. Fibronectin binds to extracellular matrix components, such as collagen, heparin sulfate proteoglycans or collagen. Furthermore, as part of the family of extracellular matrix proteins (ECM) it facilitates the delivery of growth factors to cells. Fibronectin has profound effects on wound healing, including the formation of proper substratum for migration and growth of cells during the development and organization of granulation tissue, as well as remodeling and resynthesis of the connective tissue matrix. The human Fibronectin (Fragment) is a recombinant engineered protein fragment composed of two functional domains of the full length protein.
The biological activity of human Fibronectin (fragment) was determined by adhesion assay using BHK-21 cells. Activity of human Fibronectin (fragment), premium grade, (red line) was compared to another commercially available product (black line).
The biological activity of human Fibronectin (fragment) was determined by adhesion assay using BHK-21 cells. Activity of human Fibronectin (fragment), premium grade, (red line) was compared to another commercially available product (black line).
Selected references
Shimizu, M. et al. (1997) Establishment of a standardized assay system of fibronectin activity using fibronectin-mediated cell adhesion. Biol. Pharm. Bull. 20(12): 1219-1223
View details 
