StemMACS™ TPPB is a small molecule activator of protein kinase C, also known as α-amyloid precursor protein (APP) modulator or TBP.
Background information
StemMACS™ TPPB is a potent, cell-permeable activator of Protein Kinase C (PKC) with a Ki of 11.9 nM. TPPB, also known as α-amyloid precursor protein modulator, has been shown to enhance the α-processing of amyloid precursor protein (APP). In pluripotent stem cell differentiation, TPPB has been used for increasing differentiation efficiency into Pdx-1–positive pancreatic progenitor cells.
Applications
Published applications of StemMACS TPPB include:
Differentiation of human pluripotent stem cells into insulin-producing cells1
Rezania, A. et al. (2014) Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat. Biotechnol. 32: 1121-1133
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