StemMACS™ IWR-1-endo is an inhibitor of the Wnt signaling pathway.
Background information
StemMACS™ IWR-1-endo is a potent inhibitor of the Wnt signaling pathway. It stabilizes the Axin-scaffolded destruction complex, thereby promoting β-catenin phosphorylation and degradation. In cell culture reporter assays IWR-1-endo inhibits Wnt/β-catenin signaling with an IC50 value of 180 nM.
Applications
Published applications for IWR-1-endo include:
Cardiac differentiation of human PSCs1, 2
Differentiaton of human PSCs into alveolar epithelial cells3
Ghaedi, M. et al. (2013) Human iPS cell-derived alveolar epithelium repopulates lung extracellular Matrix. J. Clin. Invest. 123(11): 4950-4962
Ren, Y. et al. (2011) Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J. Mol. Cell. Cardiol. 51: 280-287
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