StemMACS™ Thiazovivin is a selective small molecule inhibitor of Rho-associated kinase (ROCK).
Background information
StemMACS™ Thiazovivin is a selective small molecule inhibitor of Rho-associated Kinase (ROCK). Thiazovivin promotes survival and cloning efficiency of human pluripotent stem cells after enzymatic dissociation into single cells. It has been shown to increase reprogramming efficiency when combined with inhibitors of the TGF-β and MEK signaling pathways.
Applications
Published applications for Thiazovivin include:
Modulation of E-Cadherin signaling in human ES cells1
Increase of reprogramming efficiency in combination with PD0325901 and SB4315422
Xu, Y. et al. (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. U.S.A. 107(18): 8129-8134
Lin, T. et al. (2009) A chemical platform for improved induction of human iPSCs. Nat. Methods 6: 805-808
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