StemMACS™ Dorsomorphin is a small molecule inhibitor of BMP signaling and AMP-activated protein kinase.
Background information
StemMACS™ Dorsomorphin is a potent small molecule inhibitor of bone morphogenic protein (BMP) signaling. It inhibits the BMP type I receptors ALK2, ALK3 and ALK6 and prevents phosphorylation of their downstream targets Smad1, Smad5 and Smad8. BMP signaling is important for developmental patterning during embryogenesis. In pluripotent stem cell research, modulation of BMP signaling is used to direct ES and iPS cell differentiation, e.g. into neural lineages or cardiomyocytes. Dorsomorphin also acts as a reversible, ATP-competitive inhibitor of AMP-activated protein kinase (Ki = 109 nM). It is highly selective and does not inhibit structurally related kinases such as ZAPK, SYK, PKCθ, PKA and JAK3.
Zhou, J. et al. (2010) High-efficiency induction of neural conversion in human ESCs and human induced pluripotent stem cells with a single chemical inhibitor of transforming growth factor beta superfamily receptors. Stem Cells 28(10): 1741-1750
Hao, J. et al. (2008) Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS One 3: e2904
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