StemMACS™ RG108 is a selective small molecule inhibitor of DNA methyltransferase (DNMT).
Background information
StemMACS™ RG108 is a cell permeable and selective inhibitor of DNA methyltransferase (DNMT). RG108 is a non-nucleoside inhibitor that binds non-covalently and reversible to the active center (IC50 = 115 nM). It has been used as an epigenetic modifier that induces DNA demethylation and reactivation of silenced tumor suppressor genes. In pluripotent stem cell research, RG108 can enhance reprogramming efficiency.
Brueckner et al. (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 65: 6305-6311
Shi et al. (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5): 568-574
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