StemMACS™ PD0325901 is a selective small molecule inhibitor of MEK (mitogen-activated protein kinase, MAPK/ERK kinase), a key component of the Ras/Raf/MEK/ERK signaling pathway.
Background information
PD0325901 is a derivative of the MEK inhibitor CI-1040 and shows improved cell permeability and higher potency towards ERK1/2 (IC50=0.33 nM). In pluripotent stem cell research, inhibition of the MAPK signaling pathway with PD0325901 has been used to enhance reprogramming and sustain pluripotent stem cell selfrenewal.
Applications
Published applications for PD0325901 include:
Naïve, ground state culture of murine ES and iPS cells (Ying et al.)
Improved reprogramming efficiency when combined with SB431542 and Thiazovivin (Lin et al.)
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