YILIMART - ODN 1826 Control (ODN 2138) 1mg

ODN 1826 Control (ODN 2138) 1mg

For research use only

货号：: 130-100-276
描述：: ODN 1826 Control (ODN 2138)
包装：: 1 mg

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CpG ODNs are widely used for activation of immune cells or induction of signalling in TLR9-expressing recombinant cell lines.

Control compounds which contain GpC dinucleotides instead of CpGs are useful to control for the CpG specificity of this effects.

Background information

TLR9 is a prominent member of the toll-like-receptor (TLR) family recognizing pathogen-associated molecular patterns. TLR9 recognizes specifically unmethylated CpG motifs in bacterial DNA leading to activation of immune cells

^1,2

. These effects can be mimicked by short synthetical oligodeoxyribonucleotides (ODNs) containing unmethylated CpG motifs

Control compounds for CpG ODNs share the sequence with their stimulatory counterparts but contain GpC dinucleotides instead of the CpG motifs.

Applications

ODN 1826 Control (ODN 2138) can be used as a sequence control for murine B-class ODN 1826.

Selected references
1. Hemmi, H. et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745
2. Krieg, A. M. et al. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374: 546-549
3. Bauer, S. et al. (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. U.S.A. 98: 9237-9242

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ODN 1826 Control (ODN 2138) 1mg

For research use only

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Background information

Applications

Selected references

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