YILIMART - Mouse TPO (100 μg)

TPO stands for thrombopoietin, also termed thrombopoiesis stimulating factor (TSF). Mouse TPO is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse TPO may be used for a variety of applications, including:

Megakaryocyte proliferation and differentiation in vitro .
In vitro expansion of hematopoietic stem cells.
In vitro platelet activation.
Apoptosis assays.

Alternative names

MDGF

Background information

Thrombopoietin (TPO), also known as thrombopoiesis stimulating factor (TSF), is a glycoprotein hormone and the major stimulator of megakaryopoiesis and platelet production. TPO is expressed in liver, kidney, spleen, lung, bone marrow, and brain. The TPO receptor is a product of the proto-oncogene

c-mpl

and displays homology with type I cytokine receptor superfamily members. Analogous to the effect of erythropoietin (EPO), the primary mode of action of TPO is inhibition of apoptosis of its target cells. By contrast, TPO is strongly proapoptotic in the brain and acts as a counterpart of EPO which has neuroprotective properties.

Quality description

Research-grade

cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

Proliferation of human MO7e cells
research grade: ≥ 1×

10
⁶
U/mg

Certificates

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Mouse TPO (100 μg)

For research use only

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Applications

Alternative names

Background information

Quality description

Biological activity

Certificates

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