RANTES is a chemoattractant for monocytes, memory T cells, basophils, and eosinophils. RANTES is secreted by many cell types at inflammatory sites and acts through the binding to CCR1, CCR3, and CCR5 receptors. It causes the release of histamine from basophils and activates eosinophils. Furthermore, it can induce the proliferation and activation of killer cells known as CC-chemokine-activated killer (CHAK). RANTES-deficient mice show an impaired T cell function.
