MIP-3β stands for macrophage inflammatory protein 3β. Human MIP-3β is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.
Applications
Human CCL19 (MIP-3β) can be used for a variety of applications, including:
Study of lymphoid an myeloid cell migration via chemotactic assays.
Maturation of dendritic cells and induction of T cell proliferation.
Alternative names
CCL19, ELC, Exodus 3
Background information
Chemokine (C-C motif) ligand 19 (CCL19) also known as macrophage inflammatory protein 3β (MIP-3β) belongs to the family of CC-motif chemokines, characterized by four highly conserved cysteine residues. CCL19 is a chemoattractant involved in the regulation of lymphocyte circulation and homing in the thymus and secondary lymphoid organs. It is expressed in thymus and lymph nodes and binds to chemokine receptor CCR7, which is expressed on lymphocytes, such as central memory T cells, and myeloid progenitors. CCL19 is also important for migration of antigen presenting cells, such as dendritic cells and antigen-loaded B cells. Human MIP-3β is active on murine cells.
Quality description
Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.
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