The miRXplore Universal Reference is an equimolar pool of more than 950 single-stranded synthetic RNA oligonucleotides matching mature microRNAs. It represents a reliable and comprehensive microRNA reference.
Disclaimer
This product and its use are covered by one or more patents owned by Oxford Gene Technology Limited or Oxford Gene Technology IP Limited (together "OGT"): US 6, 054, 270; EP 0, 373, 203; JP 3, 393, 528 and 3, 386, 391 and pending patents. The purchaser is licensed to practice methods and processes covered by these patents using this product, but may not: transfer data derived from the use of this product to third parties for value; use this product to make, have made, create, or contribute to the creation of stand-alone expression database product for license, sale, or other transfer to a third party for value; or use this product for the identification of antisense reagents or the empirical design of probes or sets of probes for using or making nucleic acid arrays.
Applications
For miRNA microarray experiments, the miRXplore Universal Reference can be used as:
Reference
Hybridization control
Quality control for microarrays
Positive control for microRNA cloning experiments
Absolute quantification of microRNAs
Moreover, the reference can be used for real-time PCR applications, for example, as positive control and quantification tool.
Sensitivity of doubled signal detection in microRNA profiling experiments using the automated a-Hyb Hybridization Station. Comparison of automated versus manual hybridizations using the a-Hyb Hybridization Station (left) or static cover slip hybridization (right) in microRNA profiling experiments.
Sensitivity of doubled signal detection in microRNA profiling experiments using the automated a-Hyb Hybridization Station. Comparison of automated versus manual hybridizations using the a-Hyb Hybridization Station (left) or static cover slip hybridization (right) in microRNA profiling experiments.
Example of a miRXplore Universal Reference (UR) application. Direct comparison of miRNA expression in liver versus brain tissue and indirect comparison of miRNA expression in liver or brain tissue versus miRXplore UR, respectively.
A) overlay scan, B) cluster analysis.
Example of a miRXplore Universal Reference (UR) application. Direct comparison of miRNA expression in liver versus brain tissue and indirect comparison of miRNA expression in liver or brain tissue versus miRXplore UR, respectively.
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