Anti-IRF-7 (pS477/pS479)-APC, h 30 tests


For research use only
货号:
130-104-750
描述:
Anti-IRF-7 pS477/pS479-APC, human 
包装:
for 30 tests  
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原产地:




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Clone REA310 recognizes the interferon regulatory factor 7 (IRF-7) phosphorylated at serines 477 and 479 (pS477/pS479). IRF-7 is a member of the IRF family of transcription factors and a key player in the innate immune response against viral infections. Constitutive expression of IRF-7 is limited to peripheral blood lymphocytes and dendritic cells while in most cell types its expression can be induced by type I interferon. IRF-7 is sequestered in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, it becomes phosphorylated by TBK and IKK-i kinases. Phosphorylated IRF-7 migrates in the nucleus where it can activate interferon type I genes and other interferon-stimulated genes.
Additional information: Clone REA310 displays negligible binding to Fc receptors.

Alternative names

IRF7, IMD39, IRF-7H, IRF7A, IRF7B, IRF7C